NCT00153179

Who might be able to join this trial:

• People who have been diagnosed with type 2 diabetes (as defined by the National Diabetes Data Group)
• People who have a normal heart and blood vessel check-up result
• People who have not smoked for at least 1 year before joining
• Healthy volunteers with no known medical problems
• Healthy volunteers with a normal heart and blood vessel check-up result
• Healthy volunteers whose fasting blood sugar level is below 110 mg/dL
• Healthy volunteers who have not smoked for at least 1 year before joining

Who may not be able to join:

For people with type 2 diabetes:

• People with high blood pressure that is not being treated (above 140/90 mmHg)
• People with high cholesterol that is not being treated (LDL above the 75th percentile for their age)
• People who have smoked cigarettes within the past year
• People who have nerve damage that requires medication
• People who have kidney problems, including high levels of protein in the urine or high creatinine levels in the blood
• People with an abnormal heart or blood vessel check-up result
• People who have taken a type of diabetes medication called a thiazolidinedione within the past year
• Women who have gone through menopause and are taking hormone replacement therapy
• People taking ACE inhibitors or angiotensin receptor blockers (a type of blood pressure medication) should be aware that they may need to stop these for 2 weeks before taking the study drug (confirm with trial site)

For healthy volunteers:

• People with an abnormal heart or blood vessel check-up result
• People who are currently taking any prescription medications
• People whose fasting blood sugar level is 110 mg/dL or higher
• People who have smoked cigarettes within the past year

Important: Always verify eligibility with the trial site directly before applying.