NCT00390234

Who might be able to join this trial:

• You have been diagnosed with a soft tissue sarcoma (a type of cancer) of the female reproductive system, specifically uterine leiomyosarcoma, malignant mixed mullerian tumor/carcinosarcoma, or a similar cancer starting in the ovary or fallopian tube (confirmed by lab testing)
• Your cancer cannot be fully removed by surgery, has spread to other parts of the body, or is locally advanced
• If you have been treated before, there must be clear evidence (from scans or clinical assessment) that your cancer has continued to grow or spread
• Your cancer can be measured on a scan — at least one tumor measuring 20mm or larger using standard imaging, or 10mm or larger using a spiral CT scan
• The tumor being measured has not been previously treated with surgery, radiation, or similar procedures — unless it has since grown or spread
• You are reasonably active and able to care for yourself (confirm with trial site for specific activity level requirements)
• Your doctors estimate you have a life expectancy of at least 3 months
• Your blood counts are within acceptable ranges — including white blood cells, infection-fighting cells (neutrophils), and platelets (confirm with trial site for exact values)
• Your liver function, kidney function, and blood clotting results are within acceptable ranges (confirm with trial site for exact values)
• There is only a small amount (or no) protein found in your urine
• You are not pregnant or breastfeeding, and have taken a pregnancy test with a negative result
• If you are able to become pregnant, you are willing to use effective birth control during the trial and for at least 6 months after treatment ends
• You have had no more than 2 previous chemotherapy treatments for your advanced or returning cancer
• You have recovered from any side effects of previous treatments
• You have not previously been treated with a medication that targets blood vessel growth (antiangiogenic therapy)
• You have not had another active cancer in the past 5 years, except for certain early-stage skin cancers or cervical carcinoma in situ that were fully treated

Who may not be able to join:

• It has been less than 4 weeks since your last chemotherapy, experimental treatment, radiation, or major surgery (or less than 6 weeks for certain specific chemotherapy drugs)
• It has been less than 1 week since a tissue biopsy using a needle
• It has been less than 1 month since you used a clot-dissolving medication
• You have signs of cancer that has spread to the brain, or you have a primary brain tumor
• You have a known serious allergy to certain types of laboratory-made proteins or antibodies used to make the study drugs (confirm with trial site)
• You have a known allergy to substances chemically similar to the study drugs
• You have a wound, ulcer, or bone fracture that has not healed properly
• You have had a hole or tear in the intestines, a bowel blockage, an internal abdominal infection, or an abnormal connection in the abdomen in the past 28 days
• You have had a significant injury or trauma in the past 28 days
• You have a condition that causes problems with blood clotting or unusual bleeding
• You have an ongoing or uncontrolled infection, or mental health or personal circumstances that would make it difficult to follow the trial requirements
• You have serious or uncontrolled heart or blood vessel problems, including a stroke in the past 6 months, a heart attack or heart surgery in the past 6 months, serious heart failure or irregular heartbeat, uncontrolled high blood pressure, or significant circulation problems in the past 6 months
• You have had a blood clot (such as a pulmonary embolism or deep vein thrombosis) in the past 6 months
• You are HIV-positive and taking combination antiretroviral therapy
• You are currently taking part in another clinical trial or receiving another experimental treatment
• You are scheduled for or currently undergoing major surgery at the same time as this trial

Important: Always verify eligibility with the trial site directly before applying.