NCT00408590

Who might be able to join this trial:

• You must be 18 years of age or older.
• You must have ovarian cancer or primary peritoneal cancer that has come back, continued to grow, or not gone away after being treated with platinum-based and taxol-based chemotherapy.
• Your cancer must have been confirmed by a tissue sample (biopsy) of the original tumor, and you must have had both ovaries removed.
• Your cancer must be one of these specific types: serous, endometroid, mucinous, undifferentiated, clear cell, mixed epithelial, transitional cell, malignant Brenner's tumor, or adenocarcinoma (confirm with trial site if unsure of your type).
• Your blood test results taken within 7 days before joining must show that your blood counts and organ function are within acceptable ranges (confirm specific numbers with trial site).
• You must be willing and able to give your consent to take part in the trial.
• You must be willing to return to Mayo Clinic Rochester for follow-up visits.
• Doctors must expect you to live for at least 12 weeks.
• A blood test must show that you have a certain level of immunity to measles.
• Your blood must show a normal level of a protein called CEA (unless you are in a specific group within the trial called MV-NIS — confirm with trial site).
• You must be willing to provide all required blood and tissue samples as the trial needs.
• You must have disease that can be measured on a scan or physical exam, or be willing to have a keyhole surgical procedure (laparoscopy) to check how treatment is working, if your disease cannot be seen on scans after 6 treatment cycles.
• A blood test must show your immune system has a sufficient level of certain cells (CD4 cells) — confirm details with trial site.

Who may not be able to join:

• Your ovarian tumor is a type considered "low malignant potential," a stromal tumor, or a germ cell tumor.
• There is a standard treatment available to you that could cure your cancer or is very likely to extend your life.
• This is your first time the cancer has come back and it returned more than 6 months after finishing your first course of chemotherapy.
• You have a low level of physical functioning that significantly limits your daily activity (confirm with trial site).
• You have had an active infection within 5 days before joining.
• You have a history of tuberculosis (TB) or have previously tested positive for TB exposure.
• You have had another type of cancer in the past 5 years, unless it was a common type of skin cancer or a very early-stage cervical condition.
• You have received chemotherapy within the past 3 weeks, or immunotherapy or biological therapy within the past 4 weeks before joining.
• You have had major abdominal surgery involving the bowel within the past 3 weeks (minor procedures for the trial itself may not apply — confirm with trial site).
• You have ever received any viral or gene therapy treatment.
• You have not fully recovered from the side effects of previous chemotherapy.
• You have significant heart problems, including serious heart failure, coronary artery disease with symptoms, or certain irregular heart rhythms.
• You currently need blood transfusions or blood product support.
• Your cancer has spread to the brain, or you have a seizure disorder.
• You are HIV-positive or have any other condition that weakens your immune system.
• You have had an organ transplant.
• You have a history of long-term (chronic) hepatitis B or C infection.
• You are currently receiving other chemotherapy, immunotherapy, radiation therapy, or any other experimental treatment.
• You are taking any medications that could interfere with this trial (confirm with trial site).
• The disease inside your abdomen is larger than 8 cm, has spread into the liver itself, or has spread outside the abdominal area.
• You are taking steroid tablets or injections by mouth or into your veins (inhaled or skin-applied steroids may be acceptable — confirm with trial site).
• You live with or have regular close contact with a child under 15 months old, or with someone who has a weakened immune system.
• You are allergic to the measles vaccine or have had a severe reaction to it in the past.
• You are allergic to iodine (note: this does not refer to reactions to contrast d