NCT02489903

Who might be able to join this trial:

• You have been diagnosed with one of the following advanced or spreading cancers, confirmed by a lab test: small cell carcinoma (at least 3rd line treatment or platinum-resistant/refractory in 2nd line), a specific type of non-small cell lung cancer with an EGFR mutation (after prior platinum and targeted therapy), certain ovarian, fallopian tube, or related cancers (after prior platinum treatment or with platinum-resistant disease), or a high-grade neuroendocrine carcinoma from any part of the body (after prior chemotherapy).
• Your cancer can be measured on a scan using standard guidelines (RECIST v1.1).
• It has been at least 3 weeks since your last cancer treatment.
• You have previously received a platinum-based chemotherapy for your advanced cancer and either did not respond or relapsed within 6 months.
• You are 18 years of age or older.
• Doctors expect you to live for at least 12 weeks or more.
• You are reasonably well and able to carry out daily activities (confirm with trial site — this is measured using a standard scale called ECOG 0–2).
• Your blood counts, kidney function, and liver function meet certain minimum levels before starting treatment (confirm with trial site for specific numbers).
• You agree to allow the trial team and sponsor to access your past medical records, previous scans, and any stored tumor tissue samples.
• You are able to understand and sign a consent form agreeing to take part.
• If you are a woman who could become pregnant, or a man whose partner could become pregnant, you must agree to use reliable contraception during the trial and for 90 days after finishing treatment.

Who may not be able to join:

• You are currently taking part in another clinical trial involving an experimental treatment.
• You have cancer that has spread to the brain and is causing symptoms (for example, if you need increasing doses of steroids to manage them).
• You previously had to permanently stop platinum-based chemotherapy because of serious side effects (such as kidney damage, hearing loss, or severe nerve damage).
• You have had a severe allergic reaction to platinum-based drugs (such as carboplatin or cisplatin) or to certain chemotherapy drugs that are used alongside platinum in this trial.
• You have a serious ongoing medical condition that doctors feel would make it too risky for you to participate, such as uncontrolled diabetes, significant heart failure, a heart attack in the past 6 months, severe lung disease, uncontrolled infection, or uncontrolled fluid build-up in the lungs.
• You are pregnant or currently breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.