Huntington's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults (both male and female) between the ages of 21 and 75 years old.
• People with good enough vision and hearing to complete the study's thinking and memory tests, as assessed by the study doctor.
• People who are able to understand and sign a consent form agreeing to take part.
• People willing to use reliable contraception during the study (required for one specific group of participants only).
• People whose basic health measurements (like blood pressure and heart rate) fall within acceptable ranges.
• People considered generally healthy by the study doctor, with no major health concerns found through tests or physical examination.
• People who are physically and mentally able to travel to assessment centres in London, UK (a companion can accompany them if needed).
• People with Huntington's disease (HD) who carry the HD gene change (40 or more CAG repeats) and whose test scores place them in early, middle, or later stages of HD (specific score combinations will be assessed by the trial team — confirm with trial site).
• Healthy volunteers without HD who are a similar age and sex to participants with HD, and who either have no family history of HD, or have been tested and confirmed not to carry the HD gene change (fewer than 36 CAG repeats).

Who may not be able to join:

• People who have or have had another brain or nervous system condition (such as stroke, epilepsy, or brain surgery) that could affect the study's brain scans.
• People who have or have had a significant mental health condition that is not related to HD.
• People currently taking medications that affect certain specific brain targets being studied in this trial (confirm with trial site for a full list).
• People who are pregnant (confirmed by a urine test).
• People who are currently breastfeeding or plan to breastfeed during the study.
• People who cannot have an MRI scan, for example because they have a pacemaker, metal implants, metal fragments in their body, or metal particles in their eyes.
• People who have had a problem with alcohol or drug misuse within the past 3 years.
• People whose drug screening test at the start of the study shows the presence of substances such as cannabis, cocaine, opiates, or similar drugs.
• People with a history of cancer.
• People who experience claustrophobia (fear of enclosed spaces).
• People with significant back pain that would make lying still in a scanner unbearable.
• People for whom having a small tube placed in an artery would not be safe, based on a simple hand circulation test and blood tests (applies to one specific group of participants only — confirm with trial site).
• People who are unable to communicate or work with the study team for any reason.
• People who are currently in, or have recently taken part in (within the past 3 months), another clinical trial testing treatments that target the same brain processes being studied here.
• People with any other ongoing health condition that could affect their safety or the study's results.

Important: Always verify eligibility with the trial site directly before applying.