Rare disease

Huntington's Disease

Clinical trials recruiting in Australia for Huntington's Disease, a rare disease, as the public registries list them.

Also called: Huntington chorea; HD; Huntington disease; Huntington's chorea

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Sources: ClinicalTrials.gov, MedlinePlus, Orphanet Checked: 11 October 2026 Not medical advice

At a glance

6 trials recruiting in Australia

44 trials recruiting overseas

1-9 / 100 000 (Point prevalence, Greece, Validated) prevalence

Adolescent; Adult; Childhood; Elderly age of onset

11 October 2026 date last checked

Trials in Australia

This Australian count is likely to be on the low side. It counts the trials this site files under this condition; the registry’s own search is broader and also returns closely related conditions, some of which have their own page here. If you are searching widely, check the registry as well — every trial below links to its own record.

  • Recruiting Not a phased study

    Study for people with Huntington's Disease

    Where
    • Westmead Hospital, Westmead (NSW) — Recruiting
    • Monash University, Melbourne (VIC) — Recruiting
    • The Neurosciences Unit - North Metropolitan Hospital, Perth (WA) — Recruiting
    • University of Melbourne, Royal Melbourne Hospital, Parkville (VIC) — Recruiting
    Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Accepted.
    Sponsor CHDI Foundation, Inc.
    Timeline
    Started 1 July 2012 Today 16 October 2026 Estimated completion 1 January 2062

    NCT01574053 · Checked 11 October 2026

    Trial details Summary for your GP Official record and contacts
  • Recruiting Phase 2

    Phase 2 study for people with Huntington's Disease

    Where
    • Westmead Hospital, Westmead (NSW) — Recruiting
    • The University of Queensland, Herston (QLD) — Not yet recruiting
    • Calvary Health Care Bethlehem, Parkdale (VIC) — Not yet recruiting
    • The Royal Melbourne Hospital, Parkville (VIC) — Not yet recruiting
    • Perron Institute, Nedlands (WA) — Not yet recruiting
    Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.
    Sponsor Western Sydney Local Health District
    Timeline
    Started 1 June 2024 Today 16 October 2026 Estimated completion 1 November 2026

    NCT05509153 · Checked 11 October 2026

    Trial details Summary for your GP Official record and contacts
  • Recruiting Phase 3

    Phase 3 study for people with Huntington's Disease

    Where
    • Royal Darwin Hospital, Darwin (NT) — Recruiting
    Who can join Age 4 Years to 17 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.
    Sponsor Starship Child Health, Te Toka Tumai Auckland
    Timeline
    Started 17 June 2024 Today 16 October 2026 Estimated completion 1 May 2027

    NCT06259006 · Checked 11 October 2026

    Trial details Summary for your GP Official record and contacts
  • Recruiting Phase 3

    Phase 3 study for people with Huntington's Disease

    Where
    • Novartis Investigative Site, Westmead (NSW) — Recruiting
    • Novartis Investigative Site, Caulfield South (VIC) — Recruiting
    Who can join Age 21 Years to 70 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.
    Sponsor Novartis Pharmaceuticals
    Timeline
    Started 24 March 2026 Today 16 October 2026 Estimated completion 2 April 2030

    NCT07326709 · Checked 11 October 2026

    Trial details Summary for your GP Official record and contacts
  • Recruiting Phase 1

    Phase 1 study for people with Huntington's Disease

    Where
    • Westmead Hospital, Westmead (NSW) — Recruiting
    Who can join Age 21 Years to 70 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.
    Sponsor Sarepta Therapeutics, Inc.
    Timeline
    Started 12 May 2026 Today 16 October 2026 Estimated completion 30 November 2027

    NCT07536061 · Checked 11 October 2026

    Trial details Summary for your GP Official record and contacts
  • By invitation Phase 3

    Phase 3 study for people with Huntington's Disease

    Where

    No Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.

    • John Hunter Hospital, New Lambton Heights (NSW) — this site's status is not stated on the record
    • Westmead Hospital, Westmead (NSW) — this site's status is not stated on the record
    • The University of Queensland, Herston (QLD) — this site's status is not stated on the record
    • Flinders Medical Centre, Adelaide (SA) — this site's status is not stated on the record
    • Calvary Health Care Bethlehem, Caulfield South (VIC) — this site's status is not stated on the record
    • The Royal Melbourne Hospital, Parkville (VIC) — this site's status is not stated on the record
    • The Perron Institute for Neurology and Translational Science (Perron Institute), Nedlands (WA) — this site's status is not stated on the record
    Who can join Age 25 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.
    Sponsor Skyhawk Therapeutics, Inc.
    Timeline
    Started 10 April 2026 Today 16 October 2026 Estimated completion 1 December 2029

    NCT07537075 · Checked 11 October 2026

    Trial details Summary for your GP Official record and contacts

Trials overseas

44 trials for this disease are open to new participants outside Australia, as ClinicalTrials.gov listed them on 11 October 2026. Voxsanity does not publish a page for any of them; the searches below reach them at the registry.

These overseas counts are likely too high. They come from the registry’s own search, which expands a condition name to related conditions, so some of the trials counted are for a different disease in the same family.

Search ClinicalTrials.gov Search the WHO registry portal Joining a trial overseas

Trials not shown here

Some Australian trials are registered only on the Australian New Zealand Clinical Trials Registry and are not shown here. Search them at Australian Clinical Trials.

Key facts

Inheritance Autosomal dominant
Genes HTT, SLC2A3
Prevalence 1-9 / 100 000 (Point prevalence, Greece, Validated)
Age of onset Adolescent; Adult; Childhood; Elderly

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com).

About Huntington's Disease

The text below is reproduced exactly as its source published it. It has not been edited, shortened or rewritten.

Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste away. People are born with the defective gene, but symptoms usually don't appear until middle age. Early symptoms of HD may include uncontrolled movements, clumsiness, and balance problems. Later, HD can take away the ability to walk, talk, and swallow. Some people stop recognizing family members. Others are aware of their environment and are able to express emotions. If one of your parents has Huntington's disease, you have a 50% chance of getting it. A blood test can tell you if have the HD gene and will develop the disease. Genetic counseling can help you weigh the risks and benefits of taking the test. There is no cure. Medicines can help manage some of the symptoms, but cannot slow down or stop the disease. NIH: National Institute of Neurological Disorders and Stroke

US source; availability in Australia may differ.

Source: MedlinePlus Health Topics (medlineplus.gov), public domain (U.S. National Library of Medicine). Read the full source.

Sources and dates

  • ClinicalTrials.gov – trial records, statuses and site lists
  • MedlinePlus – the About text above, reproduced exactly
  • Orphanet / Orphadata – prevalence, age of onset, inheritance, genes and alternative names, used under CC BY 4.0
  • ClinicalTrials.gov processing date: 22 September 2026.
  • This page last checked by Voxsanity: 11 October 2026.

Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.

Not medical advice.

Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.

Orphanet citation

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com). Accessed 20 September 2026.

ORPHA:399

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