Phase 1 Huntington's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Part 1 (first phase):

• You have been confirmed to have a genetic change linked to Huntington's disease, with a specific gene repeat number greater than 39
• You carry a particular genetic variant (called a SNP) that this treatment is designed to target
• Your scores on standard Huntington's disease assessments show you are still largely independent and functioning at a certain level (confirm with trial site)
• You are able to read the words "red," "blue," and "green," and you speak the language used at the study site fluently
• You are able to walk without any assistance
• You weigh more than 40 kg (about 88 lbs) and your body mass index (a measure of weight relative to height) falls between 18 and 32
• You are able to have MRI scans (brain imaging) without difficulty

Part 2 (second phase):

• You have already completed the safety follow-up period after receiving the treatment in Part 1 of this study
• In the doctor's opinion, your health has not gotten worse in a way that would make it unsafe for you to continue

Who may not be able to join:

Part 1 (first phase):

• You are currently taking part in, or plan to take part in, another clinical trial, or have used certain gene-silencing or Huntington's-related experimental treatments recently
• You are pregnant, breastfeeding, or planning to become pregnant during the study or during the required period of contraception
• You have been diagnosed with cancer within the last 5 years
• You have planned brain surgery scheduled during the study
• You have tested positive for HIV, or certain types of hepatitis B at your screening appointment
• You have experienced serious mental health episodes such as psychosis, severe confusion, or violent or aggressive behaviour in the past 12 weeks
• You have a current or past diagnosis of a primary psychotic disorder (a serious mental health condition involving loss of touch with reality)
• You have a spine condition or have had spinal surgery that would make it impossible to safely receive an injection into the spinal fluid as an outpatient
• You have had a suicide attempt, or serious thoughts of suicide that required a hospital visit or change in care, within the past 12 months

Part 2 (second phase):

• You left Part 1 of the study early for any reason before completing the full follow-up period
• You are pregnant, breastfeeding, or planning to become pregnant during the study or during the required period of contraception
• You are currently taking part in, or plan to take part in, another clinical trial, or are using certain gene-silencing or Huntington's-related experimental treatments
• You have received any other experimental treatment (other than the one used in this trial) during or since completing Part 1
• You experienced a serious side effect during Part 1 that met the trial's definition of a dose-limiting event (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.