Huntington's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

This trial is looking for three different groups of participants:

Group 1 – Healthy volunteers (10–20 people):

• You are considered to be in good general health based on a doctor's review of your medical history, physical exam, blood tests, and urine tests
• You have no history or current signs of any major brain, nervous system, or mental health condition
• If you are under 60, your brain MRI scan shows no significant abnormalities; if you are 60 or older, only a small, acceptable level of age-related white matter changes on your brain scan is allowed (confirm with trial site)

Group 2 – People with Huntington's disease (HD) at Stage 3 (10 people):

• You carry a specific gene change (CAG repeat expansion between 40 and 50) linked to Huntington's disease
• You are classified as Stage 3 according to a specific HD staging system (confirm with trial site)
• You score 10 or above on a standard Huntington's disease functional assessment scale (confirm with trial site)

Group 3 – People with Huntington's disease (HD) at Stage 2 (10 people):

• You carry a specific gene change (CAG repeat expansion between 40 and 50) linked to Huntington's disease
• You are classified as Stage 2 according to a specific HD staging system (confirm with trial site)
• You fall within a specific range on a Huntington's disease progression score (confirm with trial site)

Who may not be able to join:

• You have a mental health or neurological condition — for Huntington's disease participants, any condition other than HD itself
• You have a serious ongoing medical illness affecting major organs or body systems
• Your brain scan shows a significant level of white matter changes or other notable abnormalities
• You currently drink more than 15 units of alcohol per week, have a history of alcohol misuse, or currently use recreational drugs
• You have a medical reason why you cannot have an MRI scan (for example, a metal implant)
• You experience claustrophobia (fear of enclosed spaces) or are unable to lie still for at least 30 minutes inside a scanner
• You are unwilling to avoid intense or unusual physical exercise (such as weightlifting, running, or cycling) from your pre-study visit through to the end of the scan
• You (or your guardian, if applicable) do not fully understand what the study involves
• You (or your guardian) are unwilling or unable to complete all study procedures, or the lead researcher has any other concern about your suitability
• You are currently taking blood-thinning medication (anticoagulants)
• You are currently pregnant or breastfeeding
• You are a woman who could become pregnant and are unwilling to use appropriate contraception during the study and for at least 6 months after it ends
• You are a man whose partner could become pregnant, and you are unwilling to use a condom until 90 days after the study ends (your partner should also use an effective form of contraception)

Important: Always verify eligibility with the trial site directly before applying.