Phase 2 Huntington's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to sign a consent form agreeing to take part in the trial.
• You are between 25 and 60 years old (inclusive) at the time of signing the consent form.
• You have been diagnosed with Spinocerebellar Ataxia Type 1 (SCA1), Spinocerebellar Ataxia Type 3 (SCA3), or Huntington's Disease (HD) at a mild-to-early stage, based on specific scoring systems used by doctors (confirm with trial site).
• Your diagnosis has been confirmed through genetic testing showing a specific type of gene change (an expanded DNA repeat) in the gene linked to your condition.
• There may be additional requirements to join — confirm all details with the trial site.

Who may not be able to join:

• You have any condition that would stop you from completing the trial's tests or assessments.
• You have genetic mutations in more than one disease-related gene beyond the one causing your diagnosed condition (confirm with trial site).
• You have been diagnosed with moderate or severe long-term migraines, or you have had a severe headache after a spinal tap (lumbar puncture) that needed hospital care or a special procedure to treat it.
• You have a condition affecting your brain, spine, or body that could interfere with a spinal tap procedure or make safety checks difficult.
• You have a history of blood clotting or bleeding problems, or your platelet count (cells that help blood clot) is lower than normal.
• You have an uncontrolled heart condition, a history of irregular heartbeat, an abnormal result on a heart tracing (ECG) test, or a family history of a serious inherited heart rhythm problem or sudden unexplained death.
• You have attempted suicide or have had serious thoughts of suicide with a plan that led to hospital admission or a change in your care within the last 12 months.
• You have medical, mental health, or other conditions that, in the doctor's opinion, might affect your ability to understand the trial, give consent, follow the trial rules, or complete the trial.
• You have previously been treated with a type of gene-targeting medicine called an antisense oligonucleotide or siRNA.
• You are pregnant, breastfeeding, or planning to become pregnant or breastfeed during the trial (applies to women).
• You are unable to have or tolerate MRI scans.
• There may be additional reasons that could prevent you from joining — confirm all details with the trial site.

Important: Always verify eligibility with the trial site directly before applying.