Phase 3 Cardiomyopathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been newly diagnosed with heart failure (either as an outpatient or during a hospital stay) where the heart is not pumping as strongly as it should (the pumping function is 40% or less on an ultrasound of the heart)
• You have moderate to severe heart failure symptoms affecting your daily life
• You have an irregular heart rhythm called atrial fibrillation or atrial flutter, where your heart rate was running at 110 beats per minute or higher
• After receiving standard treatment, your irregular heart rhythm was either corrected or brought under control (heart rate below 110 at rest)
• Following that treatment, your heart's pumping function recovered to 50% or above, your heart size returned to normal on ultrasound, your heart tracing (ECG) returned to normal, and a specific heart stress marker in your blood (NT-proBNP) dropped below 250 pg/ml

Who may not be able to join:

• People under 18 years of age or those who are unable to give their own consent
• People who have previously had a heart ablation procedure and cannot take rhythm-controlling medications
• People who are pregnant
• People with certain heart defects present from birth (minor defects that don't affect blood flow may still be eligible — confirm with trial site)
• People who have already been tested and found to carry a gene linked to heart muscle disease
• People likely to have specific types of heart muscle disease, such as thickened, stiff, or spongy heart muscle
• People with moderate or severe problems with their heart valves
• People with known or suspected build-up of abnormal proteins or inflammatory conditions affecting the heart (such as amyloidosis or sarcoidosis)
• People with a high number of extra irregular heartbeats (more than 10% of all heartbeats) or a history of dangerous fast heart rhythms
• People who had a long-term or permanent fast irregular heart rhythm (above 110 bpm) before their heart failure was diagnosed, even with the best treatment available
• People with significantly reduced kidney function (confirm with trial site)
• People who had a heart attack at the time of their heart failure diagnosis
• People whose atrial fibrillation or heart failure was likely caused by medications, alcohol, or recreational drug use
• People with consistently very high blood pressure (above 160 mmHg on multiple readings) or a history of blood pressure that could not be controlled
• People with inflammation of the heart muscle (myocarditis)
• People who were in a state of severe heart failure shock at the time of diagnosis
• People who survived a sudden cardiac arrest
• People whose heart muscle weakening was caused by an artificial pacemaker
• People who have a parent, child, or sibling diagnosed with a specific type of weakened heart muscle condition called dilated cardiomyopathy

Important: Always verify eligibility with the trial site directly before applying.