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Phase 1 Parkinson's Disease Trial, By Invitation
NCT06422208
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People between the ages of 55 and 80, of any sex.
- People who have been diagnosed with Parkinson's disease by a neurologist, based on the Movement Disorder Society's 2015 diagnostic guidelines.
- People who have had a Parkinson's disease diagnosis for at least 5 years.
- People whose motor symptoms respond to dopamine-based medication, shown by at least a 30% improvement on a standard motor assessment scale during an "on/off" medication test.
- People whose brain MRI shows no major abnormalities, such as fluid build-up in the brain or widespread changes to the brain's white matter.
- People who do not have significant cognitive (thinking or memory) impairment, as measured by a standard assessment tool.
- People who do not have significant untreated depression, as measured by a standard depression assessment tool.
- People who are up to date with recommended cancer screening, as confirmed by their primary doctor.
- People who are able to understand what the trial involves and are able to provide written consent to participate.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have had previous brain surgery of any kind.
- People who have previously had a thalamotomy, pallidotomy, or deep brain stimulation procedure.
- People whose condition is a form of Parkinsonism other than standard Parkinson's disease, such as atypical, secondary, or hereditary forms.
- People with a history of psychiatric conditions such as schizophrenia or psychosis that could make it difficult to follow the trial's requirements.
- People with a prior history of bleeding inside the brain, or bleeding between the brain and its surrounding membranes.
- People who have had a cancer diagnosis within the past 5 years.
- People who are unable to have an MRI scan.
- People who are expected to live less than 6 months due to other serious illnesses.
- People who have taken part in another clinical trial or received an experimental treatment within the 6 months before joining this trial.
- People who have had active heart or blood vessel problems within the 6 months before signing the consent form, including: severe heart failure; unstable chest pain or a heart attack; serious heart rhythm problems; heart or blood vessel surgery (including stent or angioplasty procedures); a stroke or mini-stroke (transient ischemic attack); bleeding around the brain (subarachnoid hemorrhage); or major blood vessel diseases such as aortic aneurysm, aortic dissection, or significant narrowing of the carotid artery.
- People with high blood pressure that remains above 160/100 mmHg despite medication, or people with severe drops in blood pressure when standing up.
- People with abnormal blood clotting results from pre-trial tests.
- People who need to take blood-thinning (anticoagulant) medication on an ongoing basis (not including antiplatelet therapy or regular anti-inflammatory pain relief such as NSAIDs).
- People with diabetes whose blood sugar is poorly controlled, as indicated by specific blood test results above set thresholds (confirm with trial site).
- People with an active infectious disease; people known to have tested positive for certain infections including HIV, Hepatitis B, Hepatitis C, and others will be assessed individually by a specialist to determine eligibility based on their current infectious status.
- People with any other illness that, in the trial investigators' judgement, would affect their ability to follow the trial plan, put their safety at risk, or affect the reliability of the trial results.
- People who are being treated with antibiotics for an active infection within one week of enrolling in the trial.
- People with known drug or alcohol dependence, a history of seizures, or any other condition or factor that the investigator believes would interfere with the trial or make participation unsuitable.
- People who are unwilling or unable to provide written informed consent.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
GP referral letter
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Trial details
Status
By Invitation
Phase
Phase 1
Sponsor
Penelope J. Hallett, Ph.D.
Registry
ClinicalTrials.gov
Start date
7 August 2024
Est. completion
1 December 2026
Where this trial is recruiting
🇺🇸 United States
Primary endpoints
Safety: number and severity of adverse events and serious adverse events
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.