Early Phase 1 Huntington's Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 64 years old (male or female).
- Your Body Mass Index (BMI) is between 19 and 35 (a measure of body weight relative to height).
- You are able to understand and sign a consent form agreeing to take part.
- You are able to follow the study's requirements, such as fasting before tests and having blood samples taken.
- You are able and willing to travel to an imaging centre in Leuven, Belgium.
- You are willing to use appropriate contraception during the study.
If you have Huntington's disease (HD) at a certain stage, you may also need to meet these additional conditions:
- Your Huntington's gene has a specific type of change (called a CAG expansion) with a count between 40 and 50.
- You are classified at a particular stage of HD (Stage 2 or Stage 3) based on standard HD assessments.
- Your score on a specific HD progression measurement falls within a certain range (confirm with trial site).
If you are a healthy volunteer (no HD), you may need to meet these conditions:
- You have no known family history of HD, OR you have been tested and confirmed to not be at genetic risk for HD.
- You are within 5 years of age and the same biological sex as a matched HD participant in the study (except for one group where matching is not required).
Who may not be able to join:
- You are currently in another clinical study, or finished one less than 30 days ago.
- You have had PET imaging (a type of body scan) in the past 12 months that, combined with this study, would exceed safe radiation limits.
- You have a medical condition or take medication that could interfere with the study, in the opinion of the study doctor.
- You are pregnant or breastfeeding.
- You currently take blood-thinning or anti-clotting medications, including aspirin.
- You have a bleeding disorder.
- You have a strong fear of needles.
- You have metal objects in your body that are not safe for MRI scans.
- You have metal objects in your body that are MRI-compatible but located in the head or neck area.
- Your blood test results show something medically significant that could put you at risk or affect the study, including testing positive for Hepatitis B, Hepatitis C, HIV-1, or HIV-2, or having other abnormal safety lab results.
- If you have HD and take antidepressants, psychiatric medications, or supplements used to treat HD — your dose must have been stable for at least 30 days before joining (confirm with trial site).
- If you are a healthy volunteer with a family history of HD but have never been tested for the Huntington's gene change.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: +32 16344280
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
The VT (volume of distribution total) of the PET radioligand will be measured with PET imaging.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.