Parkinson's Disease Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who are willing and able to give informed consent to participate.
- People who are 18 years of age or older.
- People who have been diagnosed with idiopathic Parkinson's disease that responds to levodopa (a common Parkinson's medication).
- People whose Parkinson's disease is at a moderate stage (Hoehn and Yahr stage II or III) when not on medication, as assessed at screening.
- People who experience motor fluctuations and Parkinson's symptoms that are not well controlled by medication, including movement complications that have been present for more than 4 months.
- People who have been referred for a specific type of brain surgery called bilateral STN deep brain stimulation (DBS), in line with local medical practice.
- People who the DBS surgical team considers to be a suitable candidate for the surgery.
- People who score 26 or above on a standard memory and thinking assessment (the Montreal Cognitive Assessment) while on their medication at the screening visit.
- People whose movement symptoms improve by 30% or more after taking a test dose of levodopa, as measured around 90 minutes after the dose.
- People who, despite the best available medication treatment, experience 4 or more hours per day of poor motor symptom control (recorded over a 3-day diary before the operation).
- People who have successfully completed a practice diary with at least 75% agreement with study staff responses, and who are willing and able to complete a 3-day diary at each required time point in the study.
- Women who are not currently pregnant (confirmed by a blood test), not breastfeeding, and who are either post-menopausal, surgically sterile, or willing to use an accepted form of birth control for the duration of the study (accepted methods include hormonal contraceptives, IUDs, barrier methods such as condoms or diaphragms, or having a surgically sterile partner).
- People who have been on a stable Parkinson's medication regimen for at least 2 weeks before the baseline assessments.
- People who are willing and able to attend all required study visits, complete all study procedures, and attend follow-up visits.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have medical reasons that make DBS surgery unsuitable, such as certain brain abnormalities, metallic implants in the body (for example, aneurysm clips or cochlear implants), or other significant findings that the surgeon believes would affect the ability to place the device correctly.
- People who have not been on a stable dose of their levodopa Parkinson's medication for at least 2 weeks before the screening and baseline assessments.
- People who currently have a major psychiatric condition, such as Bipolar disorder, Schizophrenia, Obsessive-Compulsive Disorder, or another psychiatric condition that the investigator believes could affect the study results or the person's ability to participate. (People with a diagnosis of Major Depressive Disorder whose symptoms are currently well managed on a stable antidepressant regimen for at least 4 weeks before screening may still be considered.) This also includes people with a current moderate or severe alcohol or substance use disorder.
- People who have attempted suicide within 3 years before the screening visit, or who are currently experiencing active thoughts of suicide as determined by a psychiatric or psychological evaluation.
- People with a medical condition — such as significant cognitive impairment, dementia, seizures, heart failure, unstable chest pain, uncontrolled diabetes, kidney failure requiring dialysis, or another serious medical condition — that could interfere with study procedures or the person's ability to participate.
- People who have been diagnosed with a terminal illness where survival is expected to be less than 12 months.
- People who will need repeated MRI scans.
- People who require certain medical treatments including diathermy (a heat-based therapy), transcranial magnetic stimulation (TMS), or electroconvulsive therapy (ECT).
- People who already have an electrical or electromagnetic implant (such as a pacemaker or neurostimulator), who plan to have one, or who use an implanted or portable medication pump of any kind.
- People who are on blood-thinning (anticoagulant) medication that cannot be safely paused for more than 5 days before surgery.
- People who have previously had brain surgery, including any ablation procedure or other neurosurgical treatment for Parkinson's symptoms on either side of the brain.
- People who are currently taking part in another clinical study (other than a sub-study of this same trial).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
If this is close to home
This page includes language about advanced illness, prognosis, or palliative care, because that is how the trial's eligibility criteria are written. Seeing it set out plainly can land hard, whether it is about you or about someone you are caring for. You do not have to be at a crisis point to talk to someone.
- Griefline — grief and loss counselling, 9am to 6pm weekdays and midday to 6pm weekends (AEST/AEDT): 1300 845 745
- Carer Gateway — practical and emotional support if you are caring for someone, 8am to 5pm weekdays: 1800 422 737
- Canteen — for 12 to 25 year olds affected by cancer, their own or a family member's: 1800 945 215
- Palliative Care Australia — directory of palliative care services near you: palliativecare.org.au
- Lifeline — 24/7, for any kind of distress, at any hour the services above are closed: 13 11 14
Palliative care is not the same as giving up on treatment, and it is not only for the last weeks of life. It is symptom and comfort care that can run alongside active treatment, including a clinical trial.
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of support and crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention.
Voxsanity is not a counselling or medical service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
GP referral letter
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Trial details
Primary endpoints
Improvement in Good On Time (GOT)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.