Phase 2 Parkinson's Disease Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who are between 50 and 80 years old at the time of joining and have been diagnosed with idiopathic Parkinson's disease (Parkinson's that does not have a known external cause) according to a specific set of recognised diagnostic guidelines.
- People who are currently taking no more than 2 medications that work on dopamine as part of their Parkinson's treatment.
- People whose Parkinson's symptoms, when assessed at their worst (before medication takes effect), fall within a mild range on a standard disease severity scale (Hoehn and Yahr score of 0–2) (confirm with trial site).
- People who received their Parkinson's diagnosis within the last 3 years.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who show a significant drop in blood pressure when moving from lying down to sitting or standing, without a matching increase in heart rate, as measured at the screening appointment (confirm with trial site).
- People who have a known allergy or have previously had a bad reaction to a specific study drug (referred to as TZ) or closely related medications.
- People who are currently taking the study drug TZ, or who are also taking certain other medications known as DZ, AZ, prazosin, or tamsulosin.
- People with a history of liver problems.
- People with a history of clinically significant anaemia (low red blood cell levels).
- People whose movement disorder is caused by something other than idiopathic Parkinson's disease, such as medication side effects or a related but distinct condition.
- People who are currently taking more than two dopamine-related medications for Parkinson's disease at the time of screening.
- People who have previously had deep brain stimulation surgery.
- People who meet the criteria for dementia according to a specific recognised standard (Movement Disorder Society Level 1 criteria).
- People with a history of traumatic brain injury or post-traumatic stress disorder.
- People who have an unstable or acute medical, psychiatric, or orthopaedic condition that could interfere with the trial.
- People whose use of medications that affect the brain and nervous system is not stable.
- People with uncontrolled major depression, bipolar disorder, or another mental health condition that the trial investigator considers serious enough to increase the risk of a harmful reaction to the study drug.
- People who are currently experiencing active thoughts of suicide, as identified by a specific standardised assessment tool used at the trial site.
- People who, in the judgement of the trial investigator, do not have sufficient capacity to understand and agree to participation in writing.
- People whose use of blood pressure medications is not stable.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Principal Investigator: Nandakumar Narayanan, University of Iowa
Phone: 319-356-2571
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Primary endpoints
Whole-blood ATP
Can't join this trial?
Data last synced from ClinicalTrials.gov: 7 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.