Phase 3 Type 2 Diabetes Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People aged between 18 and 80 years old at the time of joining; any gender is eligible.
- People who have been diagnosed with type 2 diabetes (according to Chinese Medical Association guidelines) for at least three months.
- People who have been diagnosed with a specific type of heart failure — either "heart failure with reduced ejection fraction" or "heart failure with mildly reduced ejection fraction" (according to Chinese Society of Cardiology guidelines) — for at least three months.
- People whose heart failure has been classified as stage II, III, or IV using a standard medical rating system called the NYHA classification.
- People whose heart's pumping strength (called LVEF) was measured at less than 50% within the past 12 months, using a heart scan such as an echocardiogram or similar test.
- People whose blood levels of a heart-stress marker called NT-proBNP meet certain thresholds: at least 600 pg/mL if not recently hospitalised for heart failure; at least 400 pg/mL if hospitalised for heart failure in the past 12 months; or at least 900 pg/mL if heart failure is combined with an irregular heart rhythm called atrial fibrillation or flutter.
- People who have had stable heart failure symptoms for at least three months before joining, and who have been on a consistent, guideline-based treatment plan for both heart failure and diabetes for at least two weeks before joining, with no changes to their doses during that time.
- People who are willing to participate voluntarily, sign a consent form, and potentially be followed up for more than three years.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People whose heart failure is caused by valve problems, conditions present from birth, diseases of the sac around the heart, abnormal heart rhythms, non-heart-related illnesses, kidney or liver failure, or right-sided heart failure from lung-related or other clearly identified causes.
- People who are currently experiencing a sudden worsening of heart failure, or who were hospitalised for this reason within the four weeks before joining.
- People who are planned to have a heart procedure — such as a stent, bypass surgery, or a device to help the heart beat in sync — after joining the trial, or who have had that heart-syncing device fitted within the 12 weeks before joining.
- People with serious non-heart conditions, including cancers where life expectancy is less than three years, severe mental health disorders, blood diseases, hormone or gland disorders, significantly elevated liver enzyme levels (more than three times the normal upper limit), kidney impairment shown by a creatinine blood test result above 2 mg/dL (176.82 µmol/L), or high potassium levels above 5.5 mmol/L in the blood.
- People with moderate-to-advanced chronic kidney disease, specifically where the kidney filtration rate (eGFR or CrCl) is below 45 ml/min (stage 3b or worse).
- People with a blockage in the heart's main outflow pathway, active or severe inflammation of the heart muscle, an aortic aneurysm, a tear in the aorta, or significant blood flow problems caused by unrepaired heart valves.
- People experiencing heart-related shock, dangerous uncontrolled heart rhythm problems, certain types of electrical conduction problems in the heart without a pacemaker, unstable worsening chest pain, or a recent heart attack.
- People with blood pressure that is either too high (top number at or above 180 mmHg and/or bottom number at or above 110 mmHg) or too low (top number below 90 mmHg and/or bottom number below 60 mmHg).
- People who are pregnant, planning to become pregnant, or currently breastfeeding.
- People who have taken part in another clinical drug trial within the past four weeks.
- People who have a known allergy or sensitivity to a medication called glimepiride or related substances.
- People who have taken glimepiride within the eight weeks before joining, or who have previously not tolerated it.
- People who are unwilling to follow the study's requirements and complete the research.
- People whom the trial investigator considers unable to understand or follow the study's medication instructions or procedures, for any reason.
- People whom the study doctor considers unsuitable for any other reason.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If this is close to home
This page includes language about advanced illness, prognosis, or palliative care, because that is how the trial's eligibility criteria are written. Seeing it set out plainly can land hard, whether it is about you or about someone you are caring for. You do not have to be at a crisis point to talk to someone.
- Griefline — grief and loss counselling, 9am to 6pm weekdays and midday to 6pm weekends (AEST/AEDT): 1300 845 745
- Carer Gateway — practical and emotional support if you are caring for someone, 8am to 5pm weekdays: 1800 422 737
- Canteen — for 12 to 25 year olds affected by cancer, their own or a family member's: 1800 945 215
- Palliative Care Australia — directory of palliative care services near you: palliativecare.org.au
- Lifeline — 24/7, for any kind of distress, at any hour the services above are closed: 13 11 14
Palliative care is not the same as giving up on treatment, and it is not only for the last weeks of life. It is symptom and comfort care that can run alongside active treatment, including a clinical trial.
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of support and crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention.
Voxsanity is not a counselling or medical service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Phone: +86-027-6937-8422
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
A composite endpoint of cardiovascular death, heart transplantation, or worsening heart failure (defined as rehospitalization for heart failure or an emergency heart failure visit requiring intravenous therapy).
Can't join this trial?
Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.