Phase 3 Huntington's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 25 years old or older.
• You have been diagnosed with Huntington's Disease confirmed by a genetic test, showing a specific gene change (CAG repeat of 40 or more in the HTT gene).
• Your level of day-to-day functioning, as measured by a standard Huntington's scale called the Total Functional Capacity score, is 10 or above (confirm with trial site).
• Your movement and motor symptoms, as measured by a standard score called the Total Motor Score, are rated 6 or above (confirm with trial site).
• Your ability to live independently, as measured by an Independence Score, is rated 70 or above (confirm with trial site).
• If you are a woman who could become pregnant, you must have a negative pregnancy test before starting and use two forms of birth control during the study and for 30 days after your last dose.
• If you are a man, you must agree to use birth control during the study and for 90 days after your last dose.
• You are willing to sign a consent form and follow all study rules and appointments.

Who may not be able to join:

• You have other serious health problems or conditions affecting the brain or spine that could interfere with the study or make it unsafe for you.
• You have a condition or implanted medical device that makes it difficult or impossible to have an MRI scan.
• You have been diagnosed with cancer in the last five years (some minor skin cancers may be exceptions — confirm with trial site).
• You have severe allergies or have had a serious reaction to similar drugs in the past.
• You are currently taking medications or receiving treatments that could interfere with the study.
• You have taken part in another clinical trial or taken an experimental drug within the last two months, or longer depending on the drug involved.
• You have previously received any form of gene therapy.
• You have a history of suicidal thoughts, severe depression, or have attempted suicide in the past year.
• Your liver function tests show significant abnormalities.
• You have tested positive for hepatitis B, hepatitis C, or HIV.
• You are currently pregnant, breastfeeding, or planning to become pregnant during the study.

Important: Always verify eligibility with the trial site directly before applying.