Printed from Voxsanity (voxsanity.com.au) — NCT07401654 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Phase 2 Ovarian Cancer Trial, Not Yet Recruiting
NCT07401654
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- Women between 18 and 75 years of age.
- People who have been diagnosed through a tissue sample (from surgery or biopsy) with a specific type of ovarian, abdominal lining, or fallopian tube cancer that is at an advanced stage (Stage III or IV).
- People who have at least one area of cancer that can be measured on a CT or MRI scan, and who also meet at least one of the following conditions: the cancer could not be fully removed by surgery, OR there are factors that suggest surgery may not be safe for them (such as being 75 or older, having a BMI of 40 or higher, having ongoing health conditions, being malnourished or having low protein levels in the blood, having a moderate to large amount of fluid in the abdomen, having a recent blood clot diagnosis, or having a low physical functioning score).
- People whose cancer tissue and blood show high activity of a gene called PARK2, measured by a specific scoring method on the tumour tissue (confirm with trial site).
- People who are expected to live for more than 12 weeks.
- People with a physical functioning score (ECOG) of 0, 1, or 2, meaning they are able to carry out daily activities with little to no limitation.
- People whose bone marrow, liver, and kidneys are working well enough to meet specific blood test thresholds set by the trial (confirm with trial site for exact values).
- Women who could potentially become pregnant must have a negative pregnancy test within one week before joining the trial, agree to use effective non-hormonal contraception (such as a barrier method or intrauterine device) during the study, and must not be currently breastfeeding.
- People who have recovered from most side effects of previous chemotherapy, with any remaining effects being mild (Grade 1 or lower), except for stable nerve-related symptoms or hair loss, which may be up to Grade 2.
- People who are willing to provide tissue and blood samples during the treatment period.
- People who are able to understand and follow the study requirements, including keeping to the treatment schedule, attending required tests and scans, taking part in follow-up appointments, and completing quality of life questionnaires.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who are involved in planning or running this study.
- People who are currently taking part in another clinical trial, using another experimental drug, or receiving pre-surgery treatments such as chemotherapy, radiotherapy, immunotherapy, or traditional Chinese medicine therapy.
- People who have a known allergy or sensitivity to paclitaxel or carboplatin.
- People who have difficulty swallowing or have digestive system conditions that could affect how the body processes medication.
- People who have active brain metastases causing symptoms that require surgery, radiation, or steroid treatment, or who show signs of pressure on the spinal cord.
- People who have had major surgery within the 3 weeks before starting the study and have not fully recovered.
- People who have previously been diagnosed with, or currently have, certain blood or bone marrow conditions (such as MDS or AML), or another type of cancer — with some exceptions for certain treated skin cancers or early-stage cancers (confirm with trial site).
- People who have HIV, active hepatitis B or C, severe heart conditions (such as a heart attack in the past 3 months or serious heart rhythm problems), uncontrolled seizures, unstable spinal cord compression, or a blockage of a major vein near the heart.
- People with a mental health condition that would prevent them from being able to give informed consent.
- People with uncontrolled high blood pressure, or any other condition that the trial doctors consider unsuitable for participation.
- People with a past or current medical condition that might interfere with understanding the trial results or with their ability to follow the study requirements.
- People who have received a blood or platelet transfusion within 3 days before starting the study medication.
- People who still have unresolved side effects from previous treatment rated at Grade 2 or higher, except for nerve pain, low lymphocyte counts, or skin colour changes.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Contact this trial
Phone: 008618688395806
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Status
Not Yet Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
31 January 2026
Est. completion
31 December 2027
Primary endpoints
The proportion of patients with a chemotherapy reaction score of 3 (CRS3); Incidence of grade 3-4 neutropenia
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.