Phase 2 Ovarian Cancer Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- Women aged 18 to 75 years who are willing and able to give written consent and follow the study requirements.
- People with a laboratory-confirmed diagnosis of recurring non-mucinous epithelial ovarian cancer, including serous carcinoma, clear cell carcinoma, endometrioid carcinoma, or carcinosarcoma.
- People experiencing their first or second recurrence of ovarian cancer after standard platinum-based chemotherapy, where the recurrence was diagnosed at least 6 months after the last platinum treatment.
- People assessed by the trial doctor as not suitable for surgery.
- People who have at least one measurable area of disease according to standard imaging criteria (RECIST v1.1).
- People with a good general level of physical functioning, rated 0 or 1 on a standard medical scale (ECOG scale).
- People who, if no prior genetic test for BRCA1/2 mutations exists, are willing to provide tumour tissue and/or a blood sample to determine their BRCA status (confirm with trial site if re-biopsy may not be safe).
- People who have previously used a PARP inhibitor (other than olaparib), provided the PARP inhibitor was used for more than 18 months after first-line therapy (for those with a BRCA mutation) or more than 12 months (for those without a BRCA mutation), and recurrence happened at least 12 months after the last PARP inhibitor dose.
- People with an estimated life expectancy of at least 3 months.
- People whose blood counts, liver function, kidney function, and other organ measurements meet specific minimum levels required by the trial (confirm exact values with trial site).
- Women who could become pregnant must have a negative pregnancy test within 7 days before starting treatment, must not be breastfeeding, and must use an accepted form of contraception during treatment and for 3 months after treatment ends.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People with an active autoimmune disease or a history of autoimmune disease.
- People with mucinous ovarian cancer, sex cord-stromal tumours, or other cancer types not covered by the trial.
- People with uncontrolled fluid build-up around the lungs, heart, or abdomen that cannot be stabilised despite treatment.
- People who have had another active cancer within the 2 years before starting the trial.
- People with cancer that has spread to the brain or the lining around the brain or spinal cord.
- People who have received palliative radiotherapy, certain immune-boosting agents, or anti-tumour traditional medicines within 2 weeks before starting the trial, or hormone therapy within 1 week before starting.
- People who have used immune-suppressing medications or steroid medicines above a certain dose within 2 weeks before joining the trial.
- People who have previously received immunotherapy treatments that target the immune system's response to cancer, such as PD-1, PD-L1, or CTLA-4 inhibitors, or certain immune cell therapies.
- People who have previously been treated with olaparib.
- People currently using certain medications that strongly affect how the body processes drugs (specific CYP3A inhibitors or inducers), unless a sufficient washout period has passed (confirm details with trial site).
- People who have had major surgery, an open biopsy, or a serious injury within 4 weeks before starting the trial, or who have major planned surgery scheduled during the study.
- People who have received a live vaccine within 4 weeks before starting the trial, or who plan to receive one during the study.
- People with a known immune deficiency condition, a positive HIV test, untreated chronic hepatitis B with virus levels above a certain threshold, or active hepatitis C.
- People who have previously had an organ transplant or a bone marrow/stem cell transplant from a donor.
- People with a history of interstitial lung disease or non-infectious inflammation of the lungs.
- People who have had a serious infection requiring hospitalisation within 4 weeks before starting the trial.
- People with active or significant inflammatory bowel conditions, such as Crohn's disease, ulcerative colitis, or ongoing diarrhoea requiring treatment.
- People with severe heart or blood vessel disease, or a significant history of such conditions.
- People with nerve damage in the hands or feet rated Grade 2 or higher on a standard medical scale (NCI CTCAE v5.0).
- People with a history of severe allergic reactions to other monoclonal antibody treatments, or who are currently pregnant or breastfeeding.
- People with a known allergy to any ingredient in QL1706, olaparib, carboplatin, or paclitaxel.
- People who have taken part in another clinical trial of an investigational drug or device within 4 weeks before starting this trial.
- People with any other condition that the trial doctor believes would make participation unsafe or would interfere with the trial results.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If this is close to home
This page includes language about advanced illness, prognosis, or palliative care, because that is how the trial's eligibility criteria are written. Seeing it set out plainly can land hard, whether it is about you or about someone you are caring for. You do not have to be at a crisis point to talk to someone.
- Griefline — grief and loss counselling, 9am to 6pm weekdays and midday to 6pm weekends (AEST/AEDT): 1300 845 745
- Carer Gateway — practical and emotional support if you are caring for someone, 8am to 5pm weekdays: 1800 422 737
- Canteen — for 12 to 25 year olds affected by cancer, their own or a family member's: 1800 945 215
- Palliative Care Australia — directory of palliative care services near you: palliativecare.org.au
- Lifeline — 24/7, for any kind of distress, at any hour the services above are closed: 13 11 14
Palliative care is not the same as giving up on treatment, and it is not only for the last weeks of life. It is symptom and comfort care that can run alongside active treatment, including a clinical trial.
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of support and crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention.
Voxsanity is not a counselling or medical service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Phone: 0512-67972032
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Primary endpoints
Progression-Free Survival (PFS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 16 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.